in vitro antiplasmodial activity and cytotoxic effect of (z)-2-benzylidene-4, 6-dimethoxybenzofuran-3(2h)-one derivatives

In Vitro Antiplasmodial Activity and Cytotoxic Effect of (Z)-2-Benzylidene-4, 6-Dimethoxybenzofuran-3(2H)-One Derivatives

BACKGROUND Aurones are naturally occurring compounds that belong to flavenoids family and have antiplasmodial effects. This study investigated some new aurones derivatives against chloroquine sensitive Plasmodium falciparum. Here we report the synthesis, in vitro antiplasmodial activity and cytotoxic evaluation of 11 compound from derivatives of (Z)-2- benzylidene-4, 6-dimethoxybenzofuran-3(2H)...

Synthesis and in vitro Antibacterial Activity of Some Novel 2-Amino-4, 6-D Derivatives

Heterocyclic systems are one of the most important classes of organic compounds present in nature or synthesized in laboratory. These compounds posses an array of biological activities and are employed in the treatment of commonly occurring diseases. Keeping this in view, some new 2-amino-4,6-diarylpyrimidine from chalcones were synthesized. Eight novel 2-amino-4,6-diarylpyrimidine derivatives ...

synthesis and in vitro antibacterial activity of some novel 2-amino-4, 6-d derivatives

heterocyclic systems are one of the most important classes of organic compounds present in nature or synthesized in laboratory. these compounds posses an array of biological activities and are employed in the treatment of commonly occurring diseases. keeping this in view, some new 2-amino-4,6-diarylpyrimidine from chalcones were synthesized. eight novel 2-amino-4,6-diarylpyrimidine derivatives ...

In vitro and in vivo anti-tumor effect of (Z)-3-(chloromethylene)- 6-chlorothiochroman-4-one

The anti-tumor agent, (Z)-3-(chloromethylene)-6-chlorothiochroman-4-one, could inhibit tumor cell proliferations. However, the anti-tumor activity in vivo is poorly understood. So we research the anti-tumor activity in vitro and in vivo, and the probable anti-tumor mechanism systematically in this study. The results showed that the compound CMCT was effective with tumor as the concentration-dep...

Inotropic and Chronotropic Effects of 6-Hydroxy-4- Methylquinolin-2(1H)-One Derivatives in Isolated Rat Atria

Background: Selective phosphodiesterase (PDE3) inhibitors improve cardiac contractility and may use in congestive heart failure. However, their proarrhythmic potential is the most important side effect. Methods: In this research, we evaluated the potential cardiotonic activity of six new synthesized selective PDE3 inhibitors (6-hydroxy-4-methylquinolin-2(1H)-one derivatives) using the spontan...

synthesis and in-vitro anti-bacterial activity of new thiazolidin-4-one derivatives